five.seventeen Bone-Marrow Depression Promethazine HCl and codeine phosphate oral Answer need to be utilized with caution in patients with bone-marrow depression. Leukopenia and agranulocytosis are noted, ordinarily when promethazine has actually been Employed in association with other identified marrow-harmful agents.
Like all opioids, codeine could cause Actual physical dependence. In order to avoid signs and symptoms of withdrawal, people that use codeine for some time may well feel the need to use it everyday.
Recommend individuals never to raise the dose or dosing frequency of promethazine HCl and codeine phosphate oral Alternative for the reason that critical adverse gatherings such as respiratory melancholy may perhaps arise with overdosage [see Warnings and Precautions (five.
Hypotension Notify individuals that promethazine HCl and codeine phosphate oral Alternative could lead to orthostatic hypotension and syncope. Instruct sufferers how to acknowledge symptoms of low blood pressure and how to cut down the chance of critical effects should really hypotension come about (e.
The diagnostic analysis of people with this syndrome is complicated. In arriving at a analysis, it is important to identify cases where the scientific presentation features both of those significant professional medical sickness (e.
Observational experiments have shown that concomitant usage of opioid analgesics and benzodiazepines boosts the chance of drug-associated mortality in comparison to utilization of opioids by itself.
The expense of cocaine and fish scale cocaine varies in different areas of the whole world. Once thought of as a wealthy get more info man’s drug, cocaine has now arrive down in price tag which is a great deal more available to just about any person.
Ahead of using this medication, inform your medical doctor or pharmacist if you are allergic to any of its substances; or to opioid suffering relievers (for instance morphine); or In case you have some other allergy symptoms.
Codeine was not mutagenic in the in vitro bacterial reverse mutation assay or clastogenic from the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.
The phosphate salt of codeine takes place as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and a bit soluble in Liquor. The molecular fat is 406.37. Its molecular system is C18H21NO3•H3PO4 • ½ H2O, and it's the subsequent chemical framework.
Postmarketing circumstances of respiratory despair, which include fatalities happen to be noted with utilization of promethazine in pediatric clients.
The estimated track record threat of main beginning defects and miscarriage to the indicated populace is unfamiliar. All pregnancies Have a very track record possibility of start defect, reduction, or other adverse outcomes.
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People should really recognize that this drug, regardless if taken as encouraged may lead to habit, abuse, and misuse; instruct sufferers not to share their drug with Other people and shield their drug from theft or misuse.